Long-term follow-Up of a randomized trial of two irradiation regimens for patients receiving allogeneic marrow transplants during first remission of acute myeloid leukemia.

نویسندگان

  • R A Clift
  • C D Buckner
  • F R Appelbaum
  • K M Sullivan
  • R Storb
  • E D Thomas
چکیده

1. Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RL, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD: Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 84:3473, 1994 2. Golub TR, Baker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor b to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994 3. Papadonpoulos P, Ridge SA, Boucher CA, Stocking C, Wiedermann LM: The novel activation of ABL by fusion to est-related gene, TEL. Cancer Res 55:34, 1995 4. Goulb TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917, 1995 5. Larripa I, Mecucci C, Testoni N, Bosly A, Doyen C, Tytgat H, van den Berghe H: Inversion of chromosome 12 in human malignancies. Cancer Genet Cytogenet 28:113, 1987 6. Huret JL, Brizard A, Briault S, Dreyfus B, Giraud C, Tanzer J: Two additional cases of inv(12) in human malignancies. Cancer Genet Cytogenet 32:309, 1988 7. Hasegawa Y, Sakai N, Toyama M, Ninomiya H, Abe T: Chronic myelomonocytic leukemia transformed from refractory anemia with ringed sideroblasts with a rare abnormal chromosome, inv(12). Jpn J Clin Hematol 31:75, 1990 8. Huret JL, Brizard A, Guilhot F, Couet D, Schoenwald M, Savage JRK, Tanzer J: INV(12)(p13q11) and dicentric chromosomes in a secondary leukemia with basophilia. Hametologica 75:473, 1990 9. Mathijs B, Pieter P, Caiying G, Jeroen A, Peter M: Genomic organization of TEL: The human ETS-variant gene 6. Genome Res 6:404, 1996

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Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens.

A randomized trial of 12.0 Gy versus 15.75 Gy of total body irradiation (TBI) was performed in patients with acute myeloid leukemia undergoing allogeneic marrow transplantation while in first complete remission. All patients received 120 mg/kg cyclophosphamide followed by TBI and marrow from HLA-identical siblings. Cyclosporine and methotrexate were used for prophylaxis against acute graft-vers...

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A randomized trial was performed to compare two regimens of total body irradiation in patients with chronic myeloid leukemia treated by allogeneic marrow transplantation while in the chronic phase. All patients received cyclophosphamide 120 mg/kg followed by total body irradiation and marrow from HLA-identical siblings. Cyclosporine and methotrexate were used for prophylaxis against acute graft...

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Intensive, myelosuppressive therapy is necessary to maximize outcomes for patients with acute myeloid leukemia (AML). A comparison was made of 3 aggressive postremission approaches for children and adolescents with AML in a randomized trial, CCG2891.Atotal of 652 children and adolescents with AML who achieved remission on 2 induction regimens using identical drugs and doses (standard and intens...

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Low transplant mortality in allogeneic bone marrow transplantation for acute myeloid leukemia: a randomized study of low-dose cyclosporin versus low-dose cyclosporin and low-dose methotrexate.

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Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia in First Remission: A Randomized Trial of a Busulfan-Cytoxan Versus Cytoxan-Total Body Irradiation as Preparative Regimen: A Report From the Groupe d’Etudes de la Greffe de Moelle Osseuse

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عنوان ژورنال:
  • Blood

دوره 92 4  شماره 

صفحات  -

تاریخ انتشار 1998